| Title | Development of a Low Cost Portable Fluorometry Technology and Quantification of Cannabinoids in Body Fluids |
|---|---|
| Record ID | 25466 |
| Personal Name Creator |
Valentine, J. L. (Jimmie Lloyd), 1940- ; Bryant, P. J.; Gutshall, P. L.; Gan, O. H. M.; Niu, B. H. C.; Psaltis, P. |
| Source | ix, 41 p. : ill. |
| Corporate Creator | University of Missouri--Kansas City |
| Corporate Contributor |
United States. Department of Transportation. National Highway Traffic Safety Administration |
| Publisher | United States. National Highway Traffic Safety Administration |
| Publication Date | 19770504 |
| Language | English |
| Abstract | Technology was developed for determining delta sup 9-tetrahydrocannabinol (I) and its major metabolite 11-nor-delta sup 9-tetrahydrocannabinol-9-carboxylic acid (II) in human blood plasma utilizing high pressure liquid chromatography (hplc)-ultraviolet (uv) detection. The methods were found to be capable of determining 10 ng of I or II in 1 ml of human plasma. A third type of assay method was developed for identifying in human saliva one of the major constituents of marijuana, cannabinol (III). Results indicated that III photolytically converted to a highly fluorescent compound in the absence of air. Using this technique, a limited study of marijuana smoker's saliva and saliva from non-marijuana smokers to which I and III had been added was conducted. This study demonstrated that 1 ng/ml of III can be detected in saliva. /Abstract from report summary page/ |
| Rosap ID | dot:1197 |
| Rosap URL | https://rosap.ntl.bts.gov/view/dot/1197 |
| TRT Terms | Drug tests; Marijuana; Fluorometers; Saliva |
| General Subjects | Impaired driving, Drugs |
| Classification | NTL - SAFETY AND SECURITY - SAFETY AND SECURITY; NTL - SAFETY AND SECURITY - Human Factors |
| Geographical Coverage |
United States |
| TRIS Online Accession No |
198201 |
| Contract Number | DOT-HS-4-00968 |
| Report Number | DOT-HS-804-009; NTIS-PB296836 |
| Availability | NHTSA - Behavioral Safety Research |
| Resource type | Research Paper |
| URL | https://ntlrepository.blob.core.windows.net/lib/25000/25400/25466/DOT-HS-804-009.pdf |
| Format | |
| Database | NTL Digital Repository |