NTL Record

Title	"In vivo" measurement of total gas pressure in mammalian tissue.
Record ID	38950
Personal Name Creator	Lategola, Michael T.
Corporate Creator	Civil Aeromedical Research Institute
Publisher	Civil Aerospace Medical Institute
Publication Date	19630700
Language	English
Abstract	An in vivo method for the quantitative estimation of total gas pressure in mammalian tissue has been established. This method utilizes a rigid-walled capsule specially constructed to be permeable to oxygen, carbon dioxide and nitrogen (O2, Co2, and N2), but negligible permeable to water vapor. The results obtained at equilibrium, after subcutaneous implantation of this capsule, demonstrate directly that the total gas pressure in the adjacent tissue, which is represented by the intracapsular total gas pressure, is about 40 to 50 mmHg less that the concomitant atmospheric pressure. The difference between these gas pressures is a result of the metabolic gas exchange and may, therefore, be used to detect quantitative changes in tissue gas metabolism. Work is in progress on miniaturization and modification of the capsule device so that it may be used at intravascular as well as tissue sites in a broad variety of physiological states.
Rosap ID	dot:20778
Rosap URL	https://rosap.ntl.bts.gov/view/dot/20778
TRT Terms	Metabolism; Carbon dioxide; Gases; Oxygen; Carbon; Nitrogen; Pressure; Skin; Bubbles; Absorption; Atmospheric pressure; Arteries; Veins; Capillaries; Laboratory animals; Dogs; Blood
General Subjects	Tissue metabolism; Carbon dioxide; Oxygen; Carbon; Nitrogen; Blood gases; Bubbles; Atmospheric pressure; Skin absorption; Arteries; Veins; Capillaries; Dogs as laboratory animals
Classification	NTL - AVIATION - AVIATION
Geographical Coverage	United States
Report Number	AM 63-11; DOT/FAA/AM-63/11
Resource type	Tech Report
URL	https://ntlrepository.blob.core.windows.net/lib/38000/38900/38950/AM63-11.pdf
Format	PDF
Database	NTL Digital Repository