| Title | The mitigation of physical fatigue with "spartase". |
|---|---|
| Record ID | 38951 |
| Personal Name Creator |
Nagle, Francis J.; Balke, Bruno; Ganslen, Richard V.; Davis, Audie W. |
| Corporate Creator | Civil Aeromedical Research Institute |
| Publisher | Civil Aerospace Medical Institute |
| Publication Date | 19630700 |
| Language | English |
| Abstract | Pharmacological and clinical observations have indicated that Spartase – the aspartic acid salts of potassium and magnesium – takes part in the intermediary metabolism and moderates physical fatigue. In this study attempts were made to evaluate effects of the drug on work capacity before and after episodes of physically fatiguing exercises. Work capacity was determined by a standardized treadmill test. The test was repeated after the subject had been running cross-country for a period of 60 minutes, and again after another such period of 40 minutes. In this way effects of fatigue upon functional adaptability to stress became apparent. Then, Spartase was taken orally in a prescribed dose for two weeks whereupon the same testing procedure was reapplied. The results indicated that Spartase improved the endurance performance of untrained individuals engaging in extremely fatiguing physical work. It appeared to have no effect on highly trained individuals. |
| Rosap ID | dot:20779 |
| Rosap URL | https://rosap.ntl.bts.gov/view/dot/20779 |
| TRT Terms | Physiological fatigue; Potassium; Magnesium; Salts; Drug effects; Working conditions; Physiological aspects; Blood pressure; Heart rate; Breath; Performance tests; Electrocardiography; Workload; Experiments; Human subject testing; Metabolism |
| General Subjects | Fatigue; Aspartic acid; Potassium; Magnesium; Drugs--Physiological effect; Work capacity evaluation; Blood pressure; Heart beat; Respiration; Metabolism; Performance--Testing; Treadmill exercise tests; Electrocardiography |
| Classification | NTL - AVIATION - AVIATION; NTL - AVIATION - Aviation Human Factors; NTL - SAFETY AND SECURITY - Human Factors |
| Geographical Coverage |
United States |
| Report Number | AM 63-12; DOT/FAA/AM-63/12 |
| Resource type | Tech Report |
| URL | https://ntlrepository.blob.core.windows.net/lib/38000/38900/38951/AM63-12.pdf |
| Format | |
| Database | NTL Digital Repository |