| Title | Effects of two antihistamine-containing compunds upon performance at three altitudes. |
|---|---|
| Record ID | 39028 |
| Personal Name Creator |
Higgins, E. Arnold; Davis, Audie W.; Fiorica, Vincent; Iampietro, P.F.; Vaughan, John A.; Funkhouser, Gordon E. |
| Corporate Creator | United States. Office of Aviation Medicine |
| Publisher | Civil Aerospace Medical Institute |
| Publication Date | 19680600 |
| Language | English |
| Abstract | In a study of 45 human subjects it was determined that a compound drug containing the antihistamine phenindamine did not statistically impair performance on a modified Mashburn coordinator. Another compound containing the antihistamine chlorpheniramine did impair performance. Performance was also impaired by increasing altitudes. The combined effects of the chlorpheniramine compound and increased altitude proved more detrimental to performance than the sum of the decrements that each influence caused when encountered separately. Although no significant performance decrement resulted from the administration of the phenindamine compound, undesirable side-effects were noted. |
| Rosap ID | dot:20854 |
| Rosap URL | https://rosap.ntl.bts.gov/view/dot/20854 |
| TRT Terms | Air pilots; Antihistamines; Physiological aspects; Altitude; Performance; Drug effects; Placebos; Heart rate; Temperature; Blood analysis; Amines; Performance tests; Oxygen; Motor skills; Experiments; Human subject testing |
| General Subjects | Air pilots; Drugs--Physiological effect; Antihistamines; Altitudes; Performance; Placebos (Medicine); Heart beat; Body temperature; Blood--Analysis; Oxygen; Motor ability; Vasoconstrictors; Catecholamines |
| Classification | NTL - AVIATION - AVIATION; NTL - AVIATION - Aviation Human Factors |
| Geographical Coverage |
United States |
| Report Number | AM 68-15; DOT/FAA/AM-68/15 |
| Resource type | Tech Report |
| URL | https://ntlrepository.blob.core.windows.net/lib/39000/39000/39028/AM68-15.pdf |
| Format | |
| Database | NTL Digital Repository |