| Title | Mechanisms of action of the insecticide endrin. |
|---|---|
| Record ID | 39033 |
| Personal Name Creator |
Emerson, Thomas E.; Brake, Charles M.; Hinshaw, Lerner B. |
| Corporate Creator | Civil Aeromedical Research Institute |
| Publisher | Civil Aerospace Medical Institute |
| Publication Date | 19630800 |
| Language | English |
| Abstract | Cardiovascular effects of endrin insecticide are obscure. Experiments to investigate this phenomenon were carried out on dogs and suggested mechanisms of actions have been proposed. Results show that acute administration of endrin produces bradycardia, hypertension, copious salivation, tonic-clonic convulsions, increased body temperature, leukocytosis, hemoconcentrations and decreased blood pH. Cerebral venous pressure and cerebrospinal fluid pressure elevations are also prominent features of endrin poisoning. Although most of these effects appear to be caused by endrin acting directly on the central nervous system some may result secondarily from altered cerebral hemodynamics. |
| Rosap ID | dot:20859 |
| Rosap URL | https://rosap.ntl.bts.gov/view/dot/20859 |
| TRT Terms | Air pilots; Insecticides; Poisons; Cardiovascular system; Arteries; Nervous system; Brain; Spinal cord; Laboratory animals; Dogs; Experiments; Blood analysis; Temperature; Blood pressure; Heart rate; Physiological aspects |
| General Subjects | Air pilots; Insecticides; Endrin--Physiological effect; Cardiovascular system; Arteries; Nervous system; Brain; Cerebrospinal fluid; Blood--Analysis; Body temperature; Blood pressure; Heart beat; Convulsions; Bradycardia; Hypertension; Dogs as laboratory animals |
| Classification | NTL - AVIATION - AVIATION; NTL - SAFETY AND SECURITY - Human Factors |
| Geographical Coverage |
United States |
| Report Number | AM 63-16; DOT/FAA/AM-63/16 |
| Resource type | Tech Report |
| URL | https://ntlrepository.blob.core.windows.net/lib/39000/39000/39033/AM63-16.pdf |
| Format | |
| Database | NTL Digital Repository |