| Title | Acute and chronic effects of the insecticide endrin on renal function and renal hemodynamics. |
|---|---|
| Record ID | 39050 |
| Personal Name Creator |
Reins, D.A.; Holmes, D.D.; Hinshaw, L.B. |
| Corporate Creator | Civil Aeromedical Research Institute. Aeronautical Center |
| Publisher | Civil Aerospace Medical Institute |
| Publication Date | 19631000 |
| Language | English |
| Abstract | Chronic and acute effects of the insecticide endrin on renal function were studied in dogs. Animals were exposed to endrin chronically by intramuscular injection and acutely by intravenous infusion. In acute studies dogs developed systemic hypertension and increased renal vascular resistance attributable to a sympatho-adrenal action. Basic renal autoregulation was not impaired by endrin but was masked by effects of blood borne adrenergic agents. Changes in renal function were minimal. In chronic studies dogs developed progressive systemic hypotension with variable changes in renal function and terminal renal vasodilation in some instances. Pathological findings were minimal and could be related to hemodynamic alteration in the peripheral vasculature. Results from this investigation provide no evidence for renal failure due to chronic insecticide poisoning. |
| Rosap ID | dot:20876 |
| Rosap URL | https://rosap.ntl.bts.gov/view/dot/20876 |
| TRT Terms | Air pilots; Pesticides; Insecticides; Hypertension; Chlorine organic compounds; Hydrocarbons; Poisons; Pathology; Blood analysis; Photometers; Sodium; Potassium; Urine; Heart; Lungs; Liver; Spinal column; Abdomen; Internal organs; Brain; Laboratory animals; Dogs; Medical examinations and tests |
| General Subjects | Air pilots; Pesticides; Insecticides; Endrin--Physiological effect; Kidney function tests; Renal hypertension; Chlorohydrocarbons; Hemodynamics; Sympathomimetic agents; Blood-vessels--Dilatation; Pathology; Poisons; Glomerular filtration rate; Renal artery; Renal circulation; Blood--Analysis; Creatinine; Photometry; Sodium; Potassium; Urine; Adrenal glands; Heart; Lungs; Liver; Spleen; Pancreas; Brain; Intestines; Deglutition disorders; Dogs as laboratory animals |
| Classification | NTL - AVIATION - Aviation Human Factors; NTL - AVIATION - Aviation Safety/Airworthiness; NTL - SAFETY AND SECURITY - Human Factors |
| Geographical Coverage |
United States |
| Report Number | AM 63-26; DOT/FAA/AM-63/26 |
| Resource type | Tech Report |
| URL | https://ntlrepository.blob.core.windows.net/lib/39000/39000/39050/AM63-26.pdf |
| Format | |
| Database | NTL Digital Repository |