| Title | The effects of dextroamphetamine on physiological responses and complex performance during sleep loss. |
|---|---|
| Record ID | 39271 |
| Personal Name Creator |
Higgins, E.A.; Chiles, W.D.; McKenzie, J.M.; Iampietro, P.F.; Vaughan, J.A.; Funkhouser, G.E.; Burr, M.J.; Jennings, A.E.; West, G. |
| Corporate Creator | Civil Aeromedical Institute |
| Corporate Contributor |
United States. Office of Aviation Medicine |
| Publisher | Civil Aerospace Medical Institute |
| Publication Date | 19751100 |
| Language | English |
| Abstract | On two separate occasions, performance of 10 male subjects was measured on the Civil Aeromedical Institute Multiple Task Performance Battery at 4-hour intervals for a period of 24 hours without sleep. Each subject received a capsule at 4-hour intervals beginning at 2000. On one occasion, the first three doses contained 5 mg each of dextroamphetamine sulfate followed by placebos for the remaining three capsules. On the other occasion, all capsules were placebos. Results of the experiment demonstrated that the dextroamphetamine sulfate sustained a high level of proficiency and alertness and delayed the effects of fatigue for 8 to 12 hours after the ingestion of the third and final drug capsule. Heart rate, rectal temperature, and urinary excretion rates of catecholamines were elevated with this drug. These increases could support the enhancement of proficiency and alertness demonstrated with amphetamines. Neither the subjects' feelings of fatigue nor the accuracy of their estimates of performance capabilities differed significantly in these two test conditions. |
| Rosap ID | dot:21072 |
| Rosap URL | https://rosap.ntl.bts.gov/view/dot/21072 |
| TRT Terms | Sleep; Physiological fatigue; Amphetamines; Alertness; Physiological aspects; Drug effects; Heart rate; Temperature; Urine; Amines; Performance; Experiments; Human subject testing |
| General Subjects | Sleep deprivation; Fatigue; Drugs--Physiological effect; Amphetamines; Heart beat; Body temperature; Urine--Analysis; Catecholamines; Adrenaline; Noradrenaline; Performance |
| Classification | NTL - AVIATION - AVIATION |
| Geographical Coverage |
United States |
| Report Number | FAA-AM-75-14; DOT/FAA/AM-75/14 |
| Resource type | Tech Report |
| URL | https://ntlrepository.blob.core.windows.net/lib/39000/39200/39271/AM75-14.pdf |
| Format | |
| Database | NTL Digital Repository |