| Title | Radiobiological aspects of high altitude flight : relative biological effectiveness of fast neutrons in suppressing immune capacity to an infective agent. |
|---|---|
| Record ID | 39330 |
| Personal Name Creator |
Friedberg, Wallace; Neas, Barbara R.; Faulkner, Donald N.; Hannenman, Gerald D.; Darden, E.B. |
| Corporate Creator | Civil Aeromedical Institute |
| Corporate Contributor |
United States. Office of Aviation Medicine |
| Publisher | Civil Aerospace Medical Institute |
| Publication Date | 19780200 |
| Language | English |
| Abstract | We investigated the relative biological effectiveness (RBE) of fast neutrons compared with X-rays in impeding development of immunity to an infective agent, the intestinal cestode Hymenolepis nana. Mice were irradiated with neutrons or X-rays and 2 days later given an immunizing dose of H. nana eggs. After another 2 days, the mice received a challenge dose of the eggs. Challenge egg doses were also given to sham-irradiated unimmunized and immunized controls. All mice were killed 90 to 92 hours after challenge, and the H. nana larvae (cysticercoids) that developed in the intestinal tissue were counted. An increased cysticercoid count in the irradiated mice, as compared with the count in unirradiated immunized controls, reflects suppression of immune capacity by the radiation. The results indicate a neutron RBE of 4 at 50 and 101 rad. |
| Rosap ID | dot:21118 |
| Rosap URL | https://rosap.ntl.bts.gov/view/dot/21118 |
| TRT Terms | Altitude; Aviation safety; Cosmic rays; Solar radiation; Neutrons; Health; X rays; Laboratory animals; Rats; Laboratory tests |
| General Subjects | Aeronautics--Safety measures; Altitudes; Solar radiation; Cosmic ray neutrons; X rays; Hymenolepis; Cysticercosis; Relative biological effectiveness (Radiobiology) |
| Classification | NTL - AVIATION - Aviation Safety/Airworthiness; NTL - AVIATION - Aviation Energy and Environment; NTL - ENERGY AND ENVIRONMENT - Aviation Energy and Environment |
| Geographical Coverage |
United States |
| Report Number | FAA-AM-78-8; DOT/FAA/AM-78/8 |
| Resource type | Tech Report |
| URL | https://ntlrepository.blob.core.windows.net/lib/39000/39300/39330/AM78-08.pdf |
| Format | |
| Database | NTL Digital Repository |