| Title | Reactions of Methamidophos with Mammalian Cholinesterase |
|---|---|
| Record ID | 39348 |
| Personal Name Creator |
Robinson C.P.; Beiergrohslein D.; Smith P.W; Crane C.R. |
| Publisher | Civil Aerospace Medical Institute |
| Publication Date | 19780700 |
| Language | English |
| Abstract | The lethality of methamidophos, a phosphoramidothioate, to rats (i.p. LD50, 15 mg/kg), is similar to that of such potent organophosphate compounds as parathion and paraoxon. Certain distinctive features of its chemical structure, and reported failure of cholinesterase inhibited with methamiodophos to reactivate spontaneously in insects, prompted this study of its reactions with mammalian cholinesterase to determine if the treatment of poisoning requires modification. Atropine (10 mg/kg) or pralidoxime (60 mg/kg) afforded significant protection against lethality from methamidophos (LD50's, 60 + or - 0.4 and 52 + or - 4.9 mg/kg, respectively). Partial spontaneous recovery of inhibited cholinesterase activity was observed. However, a single dose of pralidoxime, given essentially simultaneously with methamidophos, did not hasten the recovery of cholinesterase activity. |
| Rosap ID | dot:21136 |
| Rosap URL | https://rosap.ntl.bts.gov/view/dot/21136 |
| TRT Terms | Insecticides; Poisons; Physiological aspects; Mammals; Brain; Stomach; Blood analysis; Toxicity; Nervous system; Laboratory animals; Rats; Experiments |
| General Subjects | Insecticides--Physiological effect; Insecticides--Toxicology; Poisons; Brain; Stomach; Nervous system; Blood--Analysis; Organophosphorus compounds; Cholinesterase-inhibiting insecticides; Atropine |
| Classification | NTL - AVIATION - AVIATION; NTL - SAFETY AND SECURITY - Aviation Safety/Airworthiness |
| Geographical Coverage |
United States |
| Report Number | DOT/FAA/AM-78/26 |
| Resource type | Tech Report |
| URL | https://ntlrepository.blob.core.windows.net/lib/39000/39300/39348/AM78-26.pdf |
| Format | |
| Database | NTL Digital Repository |