| Title | Inhalation Toxicology: IV. Times to Incapacitation and Death for Rats Exposed Continuously to Atmospheric Hydrogen Chloride Gas |
|---|---|
| Record ID | 39482 |
| Personal Name Creator |
Crane, Charles R.; Sanders, Donald C.; Endecott, Boyd R.; Abbott, John K. |
| Corporate Creator | Civil Aeromedical Institute |
| Corporate Contributor |
United States. Office of Aviation Medicine |
| Publisher | Civil Aerospace Medical Institute |
| Publication Date | 19850500 |
| Language | English |
| Abstract | Laboratory rats were exposed continuously to measured atmospheric concentrations of hydrogen chloride (HC1) gas until they expired. The exposure time required to produce lethality was measured, as was the time at which physical incapacitation occurred. Incapacitation was defined operationally as loss of the ability to walk in a motor-driven wheel. These two endpoints, time- to-incapacitation and time-to-death, were equated to atmospheric HC1 concentration by statistically derived regression equations. The possible relationship between the effective toxic doses of HC1 gas for rats and those reported for humans is discussed. Originator supplied keywords include: Combustion toxicology; Smoke, Irritant gas; Time-to-incapacitation; Time-to- death; Aircraft cabin fire. Key Words: toxicology, inhalation, hydrogen chloride, exposure (general), rats, humans, gases, time, regression analysis, combustion, smoke, lethality, losses, equations, death, aircraft fires, lethal dosage, laboratory animals, aircraft cabins, irritating agents. |
| Rosap ID | dot:21263 |
| Rosap URL | https://rosap.ntl.bts.gov/view/dot/21263 |
| TRT Terms | Aircraft cabins; Fire; Smoke; Hydrogen inorganic compounds; Fatalities; Rats; Laboratory animals; Experiments; Time; Poisonous gases; Toxicity; Regression analysis |
| General Subjects | Aircraft cabins--Fires and fire prevention; Hydrogen chloride--Toxicology; Gases, Asphyxiating and poisonous; Rats--Mortality--Testing; Smoke; Time measurements; Regression analysis |
| Classification | NTL - AVIATION - Aviation Safety/Airworthiness; NTL - SAFETY AND SECURITY - Aviation Safety/Airworthiness |
| Geographical Coverage |
United States |
| Report Number | FAA-AM-85-4; DOT/FAA/AM-85/4 |
| Resource type | Tech Report |
| URL | https://ntlrepository.blob.core.windows.net/lib/39000/39400/39482/AM85-04.pdf |
| Format | |
| Database | NTL Digital Repository |