| Title | Inhalation Toxicology: VII. Times to Incapacitation and Death for Rats Exposed Continuously to Atmospheric Acrolein Vapor |
|---|---|
| Record ID | 39504 |
| Personal Name Creator |
Crane, Charles R.; Sanders, Donald C.; Endocott, Boyd R.; Abbott, John K. |
| Corporate Creator | Civil Aeromedical Institute |
| Corporate Contributor |
United States. Office of Aviation Medicine |
| Publisher | Civil Aerospace Medical Institute |
| Publication Date | 19860500 |
| Language | English |
| Abstract | Acrolein, an organic aldehyde (CH2=CH-CHO), is extremely irritating to the respiratory passages at very low concentrations. It is known to be present in the smoke from certain materials used in aircraft cabin interiors and could contribute, therefore, to an individual's failure to escape from a burning aircraft. In order to assess acrolein's ability to produce physical incapacitation in a mammal, laboratory rats were exposed continuously to measured atmospheric concentrations of acrolein vapor until they expired. The exposure time required to produce lethality was measured, as was the time at which physical incapacitation occurred. Incapacitation was defined operationally as loss of the ability to walk in a motor-driven wheel, which was enclosed in the exposure chamber. Dose-response curves were generated by equating these two endpoints, time-to-incapacitation and time-to-depth, to the atmospheric acrolein concentration via statistically derived regression equations. Experimental results suggest that the acrolein dose that will produce physical incapacitation could be 10 to 100 times greater than has been predicted in the past. The possible relationship between the effective toxic doses of acrolein for rats, and those required for humans, is discussed. |
| Rosap ID | dot:21285 |
| Rosap URL | https://rosap.ntl.bts.gov/view/dot/21285 |
| TRT Terms | Air transportation crashes; Aircraft cabins; Poisonous gases; Flammable materials; Toxicology; Smoke; Aldehydes; Respiratory system; Laboratory animals; Rats; Laboratory tests; Regression analysis |
| General Subjects | Aircraft accidents; Aircraft cabins; Flammable materials; Smoke--Physiological effect; Acrolein--Toxicology; Gases, Asphyxiating and poisonous; Respiration; Regression analysis; Rats as laboratory animals |
| Classification | NTL - AVIATION - Aviation Energy and Environment; NTL - AVIATION - Aviation Safety/Airworthiness; NTL - SAFETY AND SECURITY - Aviation Safety/Airworthiness; NTL - SAFETY AND SECURITY - Accidents |
| Geographical Coverage |
United States |
| Report Number | DOT/FAA/AM-86/5 |
| Resource type | Tech Report |
| URL | https://ntlrepository.blob.core.windows.net/lib/39000/39500/39504/AM86-05.pdf |
| Format | |
| Database | NTL Digital Repository |