| Title | Inhalation Toxicology: VIII. Establishing Heat Tolerance Limits for Rats and Mice Subjected to Acute Exposures at Elevated Air Temperatures |
|---|---|
| Record ID | 39510 |
| Personal Name Creator |
Crane, Charles R.; Sanders, Donald C. |
| Corporate Creator | Civil Aeromedical Institute |
| Corporate Contributor |
United States. Office of Aviation Medicine |
| Publisher | Civil Aerospace Medical Institute |
| Publication Date | 19860500 |
| Language | English |
| Abstract | Experimental animal subjects are used most commonly to assess the toxicity of thermal decomposition products (smoke) from burning materials. Nascent smoke is obviously quite hot; therefore, the design of smoke toxicity assay systems must provide for adequate cooling of the gases prior to exposure of the animals. This research has addressed the question of how much cooling is required. Rats and mice were exposed to elevated air temperatures over the range of 38 OC to 110 OC. The exposure duration required to produce hyperthermic collapse (physical incapacitation) was measured for each temperature. A graph of time-to-collapse as a function of exposure temperature was constructed for each species and statistically derived equations were fit to each data set. Times-to-collapse ranged, for the rat, from 60 minutes at 40 OC to less than 4 minutes at 110 OC. For the mouse, they ranged from approximately 60 minutes at 40 OC to 2.5 minutes at 90 OC. The significance of these findings as they relate to smoke toxicity testing is discussed. |
| Rosap ID | dot:21291 |
| Rosap URL | https://rosap.ntl.bts.gov/view/dot/21291 |
| TRT Terms | Air transportation crashes; Physiological aspects; Heat transfer; Thermal stresses; Atmospheric temperature; Experiments; Laboratory tests; Rats; Laboratory animals |
| General Subjects | Aircraft accidents; Heat--Physiological effect--Testing; Heat--Transmission Temperature--Physiological effect--Testing; Atmospheric temperature--Physiological effect; Rats as laboratory animals |
| Classification | NTL - AVIATION - Aviation Safety/Airworthiness; NTL - SAFETY AND SECURITY - Accidents; NTL - SAFETY AND SECURITY - Aviation Safety/Airworthiness |
| Geographical Coverage |
United States |
| Report Number | DOT/FAA/AM-86/8 |
| Resource type | Tech Report |
| URL | https://ntlrepository.blob.core.windows.net/lib/39000/39500/39510/AM86-08.pdf |
| Format | |
| Database | NTL Digital Repository |