| Title | Inhalation Toxicology: XI. The Effect of Elevated Temperature on Carbon Monoxide Toxicity |
|---|---|
| Record ID | 39546 |
| Personal Name Creator |
Sanders, Donald C.; Endecott, Boyd R. |
| Corporate Creator | Civil Aeromedical Institute |
| Corporate Contributor |
United States. Office of Aviation Medicine |
| Publisher | Civil Aerospace Medical Institute |
| Publication Date | 19901200 |
| Language | English |
| Abstract | Laboratory rats were exposed (a) to experimental concentrations of carbon monoxide in air at ambient temperature, (b) to elevated temperature atmospheres from 40 C to 60° C, and (c) to selected carbon monoxide (CO) concentrations at the elevated temperatures in (b). The incapacitating potency of each of the environments was evaluated by measurement of time-to-incapacitation (ti) as a function of CO concentration and/or temperature; incapacitation was defined operationally as loss of ability to walk inside a motor-driven, rotating cage enclosed in an exposure chamber. Comparison of data from the combined (CO + elevated temperature) exposures and exposures to CO and elevated temperatures alone indicated that incapacitation occurred earlier when CO inhalation was combined with a whole-body, elevated temperature environment than was observed for the same exposure parameters applied individually. No evidence for a synergistic effect was noted. An empirical equation was derived that allows the calculation of a predicted ti for combinations of CO and temperature within the ranges utilized in the experimental exposures. |
| Rosap ID | dot:21327 |
| Rosap URL | https://rosap.ntl.bts.gov/view/dot/21327 |
| TRT Terms | Poisonous gases; Toxicity; Heat; Carbon monoxide; Physiological aspects; Laboratory tests; Laboratory animals; Rats |
| General Subjects | Gases, Asphyxiating and poisonous--Toxicology; Carbon monoxide--Physiological effect--Testing; Heat; Rats as laboratory animals |
| Classification | NTL - AVIATION - Aviation Energy and Environment; NTL - AVIATION - Aviation Safety/Airworthiness; NTL - SAFETY AND SECURITY - Aviation Safety/Airworthiness |
| Geographical Coverage |
United States |
| Report Number | DOT/FAA/AM-90/16 |
| Resource type | Tech Report |
| URL | https://ntlrepository.blob.core.windows.net/lib/39000/39500/39546/AM90-16.pdf |
| Format | |
| Database | NTL Digital Repository |